Post by Admin on Aug 4, 2005 10:50:42 GMT 1
Subject : New developments in Laminitis Research and prev. strategies
From : Exmoor Di
Date : 06.02.04 12:03:00 AM
Thought you'd all be interested. I was just reading a review from the American Association of equine Practitioners. It details new developments in the research behind the causes/preventative strategies to name a few!
One thing I thought particularly interesting was the link found between Streptococcus Bovis and S.Equus and laminitis. They proliferate rapidly when otherwise undigested carbohydrate (especially fructans) enter the hind gut. Thus, lots of D-lactate is produced (lactic acid!) and this lowers the hind gut pH. Scientists have found that pH falls from 4hrs after feeding high levels of undigestible carbos, so this is a very useful diagnostic tool. Low pH is maintained until treatment, or more than24hrs..
As well as this, there is new hope in helping to prevent detachment of the laminae. In order for enzymes to do this, increased blood flow is required. So, cryotherapy may soon be routinely used in the emergency treatment of acute laminitis. So, coldhosing feet is no only a good thing - it could save the life of your horse. Of course, cryotherapy implies FREEZING the feet, easier said than done, but that pack of frozen peas might not just be used for sprains in the future!!!
Research is ongoing in finding inhibitors of the enzymes which do the damage.
There's lots of papers on it at the mo - I get the info through IVIS (International Veterinary Information Service) of which I managed to get membership as a member of the medical profession! Most scientists are eligible, so go for it if you're a boffin.
Subject : re:- New developments in Laminitis Research and prev. strategies
From :
Date : 06.02.04 12:08:00 AM
So.. lactic acid build up in the hind gut which lowers the pH... and this can cause laminitus yeah??
Well.. I was just thinking, probiotics can produce high levels of lactic acid, so would probiotics be a bad thing to give to a laminitic at the time of yeah when fructans are high??
Subject : re:- New developments in Laminitis Research and prev. strategies
From :
Date : 06.02.04 12:12:00 AM
I think J taylor told us not to feed pro b's to laminitics or those at risk.
do a search under 'supplements for laminitics' or just laminitis/cs and see what comes up.
I could be wrong but was it brewers yeast and yeaa sacc that should be fed instead?
im interested in more research as though my horse isnt lam, is def a fat welshie in spring and therefore more at risk!
Subject : re:- New developments in Laminitis Research and prev. strategies
From : alice
Date : 06.02.04 12:24:00 AM
i have upped a thread that may be of interest (probiotics vs live yeast). I was querying the prescribing of probiotics for my laminitic (as was Jackie who was able to explain it much better!) - good to see there is finally beginning to be some recognition ....
Subject : re:- New developments in Laminitis Research and prev. strategies
From :
Date : 06.02.04 2:53:00 PM
Yes, both prebiotics (FOS) and probiotics (live lactic acid bacteria) increase lactic acid production in the hindgut and take a horse one (maybe small) step closer to laminitis.
Yea-Sacc does the opposite - I don't know about generic brewers yeast.
I would say a word of caution about cold-hosing/icing etc. Laminitis they think results from ischemia (loss of blood flow) and reperfusion injury(restoration of blood flow) when the tissues inflame, and the pain occurs.
So, by the time your horse is showing clinical signs of laminitis it is PAST what is called 'the developmental stage'.
However, Pollit I believe found that in experimental laminitis, icing the feet AT EXACTLY THE RIGHT TIME could prevent laminitis, he hypothesised by reducing the toxins from carbohydrate overload, or other 'trigger factors', being 'delivered' to the feet - and so reduce the damage caused BY THEM.
So, for instance this could mean that if your horse breaks into the feed room, or into the cow pasture, we may be able to say OK, ice his feet for the first 48 hrs after the event, and it will help reduce the damage because it will reduce 'delivery'.
It may do no good at all after the developmental stage - ie by the time you see any lameness it may be too late. It may reduce his pain then as it reduces inflammation, but the jury is out as to whether it might do some harm by reducing circulation - at that stage. By then a horse is normally being treated with anti-inflammatories and vasodilators in an attempt to RESTORE normal circulation so that the harmful products of inflammation can be removed, and healing can begin.
PLUS, there are several causes of laminitis that are thought to be more due to chronically reduced circulation, such as with insulin resistance and Cushing's disease. In these cases it may be the last thing you want to do - so I would be very careful for now.
Jackie
Subject : re:- New developments in Laminitis Research and prev. strategies
From : Exmoor Di
Date : 06.02.04 5:09:00 PM
Should have clarified that bit, but I was reading so much! Yes, they did say that this was in the developmental stage.
Subject : New developments in Laminitis Research and prev. strategies
From : KATHY
Date : 04.03.04 3:52:00 PM
Hi
Thought you'd like to know that the April issue of HORSE mag has an in depth article on laminitis, fructans and prebiotics, and includes the opinions of Jackie Taylor and Chris Pollitt to name a few!
Subject : re:- New developments in Laminitis Research and prev. strategies
From : Katie L
Date : 04.03.04 7:39:00 PM
Jackie
"Yes, both prebiotics (FOS) and probiotics (live lactic acid bacteria) increase lactic acid production in the hindgut and take a horse one (maybe small) step closer to laminitis."
Do you have any references to back this statement up, that actually show an acidifying effect?
Subject : re:- New developments in Laminitis Research and prev. strategies
From : JackieJATaylor
Date : 05.03.04 0:46:00 AM
All the studies on lactic acid bacteria probiotics shows they acidify the gut in every species tested - that is the whole point of a probiotic. FOS selectively feed LAB.
If you key in 'pH lactobacillus' into Pubmed 7,700 papers will be listed.
Cuddeford and Townsend backed up everything I suggest, and the Horse article is based on Pollit and Longlands explaining how fructans cause laminitis associated with acidification of the hindgut. A Cuddeford said, in animals that do not ferment fibre that's a benefit. In a horse, it's a risk.
No research has been done in horses, though we know Founderguard prevents acidosis and laminitis by suppressing LAB growth.
Jackie
From : Exmoor Di
Date : 06.02.04 12:03:00 AM
Thought you'd all be interested. I was just reading a review from the American Association of equine Practitioners. It details new developments in the research behind the causes/preventative strategies to name a few!
One thing I thought particularly interesting was the link found between Streptococcus Bovis and S.Equus and laminitis. They proliferate rapidly when otherwise undigested carbohydrate (especially fructans) enter the hind gut. Thus, lots of D-lactate is produced (lactic acid!) and this lowers the hind gut pH. Scientists have found that pH falls from 4hrs after feeding high levels of undigestible carbos, so this is a very useful diagnostic tool. Low pH is maintained until treatment, or more than24hrs..
As well as this, there is new hope in helping to prevent detachment of the laminae. In order for enzymes to do this, increased blood flow is required. So, cryotherapy may soon be routinely used in the emergency treatment of acute laminitis. So, coldhosing feet is no only a good thing - it could save the life of your horse. Of course, cryotherapy implies FREEZING the feet, easier said than done, but that pack of frozen peas might not just be used for sprains in the future!!!
Research is ongoing in finding inhibitors of the enzymes which do the damage.
There's lots of papers on it at the mo - I get the info through IVIS (International Veterinary Information Service) of which I managed to get membership as a member of the medical profession! Most scientists are eligible, so go for it if you're a boffin.
Subject : re:- New developments in Laminitis Research and prev. strategies
From :
Date : 06.02.04 12:08:00 AM
So.. lactic acid build up in the hind gut which lowers the pH... and this can cause laminitus yeah??
Well.. I was just thinking, probiotics can produce high levels of lactic acid, so would probiotics be a bad thing to give to a laminitic at the time of yeah when fructans are high??
Subject : re:- New developments in Laminitis Research and prev. strategies
From :
Date : 06.02.04 12:12:00 AM
I think J taylor told us not to feed pro b's to laminitics or those at risk.
do a search under 'supplements for laminitics' or just laminitis/cs and see what comes up.
I could be wrong but was it brewers yeast and yeaa sacc that should be fed instead?
im interested in more research as though my horse isnt lam, is def a fat welshie in spring and therefore more at risk!
Subject : re:- New developments in Laminitis Research and prev. strategies
From : alice
Date : 06.02.04 12:24:00 AM
i have upped a thread that may be of interest (probiotics vs live yeast). I was querying the prescribing of probiotics for my laminitic (as was Jackie who was able to explain it much better!) - good to see there is finally beginning to be some recognition ....
Subject : re:- New developments in Laminitis Research and prev. strategies
From :
Date : 06.02.04 2:53:00 PM
Yes, both prebiotics (FOS) and probiotics (live lactic acid bacteria) increase lactic acid production in the hindgut and take a horse one (maybe small) step closer to laminitis.
Yea-Sacc does the opposite - I don't know about generic brewers yeast.
I would say a word of caution about cold-hosing/icing etc. Laminitis they think results from ischemia (loss of blood flow) and reperfusion injury(restoration of blood flow) when the tissues inflame, and the pain occurs.
So, by the time your horse is showing clinical signs of laminitis it is PAST what is called 'the developmental stage'.
However, Pollit I believe found that in experimental laminitis, icing the feet AT EXACTLY THE RIGHT TIME could prevent laminitis, he hypothesised by reducing the toxins from carbohydrate overload, or other 'trigger factors', being 'delivered' to the feet - and so reduce the damage caused BY THEM.
So, for instance this could mean that if your horse breaks into the feed room, or into the cow pasture, we may be able to say OK, ice his feet for the first 48 hrs after the event, and it will help reduce the damage because it will reduce 'delivery'.
It may do no good at all after the developmental stage - ie by the time you see any lameness it may be too late. It may reduce his pain then as it reduces inflammation, but the jury is out as to whether it might do some harm by reducing circulation - at that stage. By then a horse is normally being treated with anti-inflammatories and vasodilators in an attempt to RESTORE normal circulation so that the harmful products of inflammation can be removed, and healing can begin.
PLUS, there are several causes of laminitis that are thought to be more due to chronically reduced circulation, such as with insulin resistance and Cushing's disease. In these cases it may be the last thing you want to do - so I would be very careful for now.
Jackie
Subject : re:- New developments in Laminitis Research and prev. strategies
From : Exmoor Di
Date : 06.02.04 5:09:00 PM
Should have clarified that bit, but I was reading so much! Yes, they did say that this was in the developmental stage.
Subject : New developments in Laminitis Research and prev. strategies
From : KATHY
Date : 04.03.04 3:52:00 PM
Hi
Thought you'd like to know that the April issue of HORSE mag has an in depth article on laminitis, fructans and prebiotics, and includes the opinions of Jackie Taylor and Chris Pollitt to name a few!
Subject : re:- New developments in Laminitis Research and prev. strategies
From : Katie L
Date : 04.03.04 7:39:00 PM
Jackie
"Yes, both prebiotics (FOS) and probiotics (live lactic acid bacteria) increase lactic acid production in the hindgut and take a horse one (maybe small) step closer to laminitis."
Do you have any references to back this statement up, that actually show an acidifying effect?
Subject : re:- New developments in Laminitis Research and prev. strategies
From : JackieJATaylor
Date : 05.03.04 0:46:00 AM
All the studies on lactic acid bacteria probiotics shows they acidify the gut in every species tested - that is the whole point of a probiotic. FOS selectively feed LAB.
If you key in 'pH lactobacillus' into Pubmed 7,700 papers will be listed.
Cuddeford and Townsend backed up everything I suggest, and the Horse article is based on Pollit and Longlands explaining how fructans cause laminitis associated with acidification of the hindgut. A Cuddeford said, in animals that do not ferment fibre that's a benefit. In a horse, it's a risk.
No research has been done in horses, though we know Founderguard prevents acidosis and laminitis by suppressing LAB growth.
Jackie